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In differentiated adipocytes, BCAA catabolic flux increases, and BCAA-derived acetyl-CoA accounts for approximately 30% of the lipogenic acetyl-CoA pools 3,63

The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin

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