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Cell Metabolism (2022) 6
At that temperature, degradation proceeds roughly 4x faster than at 4C (based on the Arrhenius rate doubling per 10C)
REDEFINE 2, in adults with overweight or obesity and type 2 diabetes, reported a 13.7% mean reduction at 68 weeks versus 3.4% on placebo (Lingvay et al., 2025)
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