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Further studies are needed to define the optimal dose range of arctigenin and generate a no observed adverse effect level and a lowest observed adverse effect level

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DOI: 10.1056/NEJMoa1616011 [Google Scholar] Kaul S

A complex network of the m6A-metabolite-TME axis has been proposed, i.e., the ability of m6A to induce aberrant changes in metabolite levels, which may in turn trigger oncogenic signaling pathways leading to significant alterations within the TME [43]

References [1] Sigalos, J.T., & Pastuszak, A.W