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The peptide underwent testing for its potential advantages in patients suffering from post-surgical ileus, a condition related to lack of peristalsis manifesting after gastrointestinal surgery

We also found that GLP-1RAs had anti-calcification effects via inhibition of osteoblastic differentiation in Pi-treated VSMCs, which was mediated by Atf4 inhibition

These differences help explain why GLP-1 drugs work best for people whose obesity is rooted in gut hormone dysfunction, while those with brain-based appetite signaling issues may respond better to older medications or drug combinations