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Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration
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In comparison to the control, growth of MRAB isolates in presence of amikacin were significantly reduced from 6 g/ml amikacin for MRAB-1 and -2, and from 8 and 10 g/ml amikacin for MRAB-3 and -4, respectively (B)
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