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In contrast, therapeutic strategies targeting other HSPs, including HSP70, HSP27, and B-crystallin, remain at an earlier stage but have demonstrated encouraging results in preclinical cardiovascular models
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In research discussions, its usually framed as a repair and inflammation-focused blend rather than a single-pathway tool
Collectively, above evidence shows that natural products may serve as effective therapeutic agents in DKD management
Metformin, as an AMPK activator, inhibits the AMPK-mTOR-STAT3 axis, reduces mtDNA mutations and ROS generation in lupus models, and enhances mitophagy
Trivedi MS, et al
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