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Acknowledgements The authors acknowledge support from the National Institutes of Health (grants R01-CA131524, P01 CA025874 and 5T32CA177555-02), the Gerson and Barbara Bass Bakar Distinguished Professorship in Cancer Research and the Terry Patters Memorial Foundation

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This activation promotes mitochondrial biogenesis, oxidative metabolism, and muscle glucose uptake, thereby improving muscle function and insulin sensitivity in T2D and sarcopenia

Prolonged exposure to arsenic metabolites can result in severe and widely varied harmful consequences to health and could include increased risk of skin and lung malignancies, neurological dysfunctions, hypertension and cardiovascular anomalies

At this time, there are no known adverse reactions when taken in conjunction with medications