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The core cycle responsible for methylation, known as the folate-methionine cycle, relies on active forms of vitamin B12 (methylcobalamin), folate, and B6 to produce S-adenosylmethionine (SAM)
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Interestingly, the same study found that, in rats, tirzepatide suppressed lipid intake without affecting sucrose (carbohydrate) consumption in a choice-based assay, implying that the effects of these medications may be macronutrient specific (Geisler et al., 2023)
Additionally, some individuals may experience digestive issues or nausea, which can contribute to feelings of tiredness
10.3390/ijms17020189 Int
There's also a hunger-hormone angle: ghrelin, the "hunger hormone" produced by the stomach when it's empty, is decreased by GLP-1 receptor agonists, which contributes to their appetite-suppressing effects
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