6h, Supplementary Fig
Drugs like Ozempic, Wegovy, Mounjaro, and Zepbound dominate headlines, social media discussions, and increasingly, medicine cabinets across the country
doi: 10.1007/s10557-021-07220-z 12 ZengYCaoGLinLZhangYLuoXMaXet al
Notably, the observed reductions in the odds of substance use disorders, including a 74% decrease in the odds of AUD, a 69% reduction for OUD, a 68% reduction for NUD, and a 75% reduction for CUD, among GLP-1 RA users were consistent with emerging preclinical and clinical studies showing that GLP-1 RA modulates reward pathways in the brain to reduce SUD (17, 23)
Both classes share the same primary side effects (nausea, occasional vomiting, constipation, reflux, fatigue in the early weeks)
Combination drugs like Qsymia (phentermine-topiramate) and Contrave (naltrexone-bupropion) are also noted for their effectiveness