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Injection site selection can also play a minor role

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Causes (Why IBS Happens) IBS is usually a mix of factors : Gutbrain communication changes (nerves become extra sensitive) Altered motility (colon moves too fast or too slow) Microbiome shifts after infection, antibiotics, or stress Food triggers (e.g., highFODMAP foods, excess caffeine) Stress, anxiety, or poor sleep (they dont cause IBS but can magnify it) Pathophysiology (In Simple Terms) Think of the gut like a microphone turned up too loud: Visceral hypersensitivity: normal gas/stretch feels painful

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Almost 20% of the identified patients who initiated GLP1-RA stopped treatment within the first 12 months, the majority due to undesired side effects or a lack of effect

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