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The drugs bring people to their factory settings by mimicking the GLP-1 hormone, which the body uses as a signal to help the brain decide when to stop eating and when to seek out more food
GLP-1 receptor agonists work by: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood glucose levels without causing excessive hypoglycaemia Suppressing glucagon release from alpha cells, reducing hepatic glucose production Slowing gastric emptying , which prolongs the feeling of fullness after meals Acting on appetite centres in the brain , particularly the hypothalamus, to reduce hunger and food intake These medications are administered via subcutaneous injection, typically once weekly or once daily depending on the specific formulation
Tirzepatides effect on metabolism is still being studied, but it is possible that similar adaptations could occur
Phase 3 trials (the TRIUMPH programme) are currently underway to evaluate retatrutide's long-term safety, cardiovascular outcomes, and efficacy across broader patient populations
(2016b)
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