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Its value in a clinical setting comes from what it is not: it does not disrupt appetite, hormones, insulin, or IGF-1

for more details, see Sampson et al., 2021 13

Microbiome differences were greater between the two groups switched from WD to LD (i.e., WD/LD-V and WD/LD-T) and the two diet control groups (i.e., LD/LD-V and WD/WD-V) compared to the microbiome differences observed between the lean (LD/LD-V) and obese (WD/WD-V) control groups

When NNMT levels are high, its harder for people to lose weight

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