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Beyond physical health, obesity often carries substantial psychological and social burdens, such as depression, stigma, and reduced self-esteem [6]
In the absence of curative conventional treatment, researchers, clinicians, and patients are increasingly seeking out alternative therapies to find more complete symptom relief and potentially delay progression
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G., Douroudos, I., Panagoutsos, S., Pasadakis, P., Nikolaidis, M
Melanotan-2 tolerance is receptor-mediated (downregulation of melanocortin receptors), whereas GLP-1 agonist tolerance primarily involves gastric adaptation and reduced side effect intensity rather than loss of therapeutic effect
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