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This differential effect of G49 and Fc-GLP1 was supported by the analysis of cFos positive POMC neurons in the ARC, indicating that G49-mediated effects on EE significantly contribute to the body weight loss

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Studies in mice and humans showed that GLP-1 liraglutide acts directly and indirectly in LDL and VLDL catabolism, increases lipoprotein lipase gene expression responsible for TAG hydrolysis, and reduces apolipoprotein B48, diacylglycerol O -acyltransferase 1, and microsomal transfer protein gene expression, all of which are involved in chylomicron synthesis [77, 78]

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