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For procurement organizations, this shift introduces new complexities, including supply chain constraints, pricing pressures, geopolitical risks, and capacity limitations

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Key end points included: hospitalisation, heart failure (ICD-10-CM-I50), myocardial infarction (ICD-10-CM-I21), stroke and transient ischaemic attack (ICD-10-CM-I63, G45), development of diabetic microvascular complications (ICD-10-CM-E10.210.4) and all-cause mortality analysed 3 months to 5 years post drug initiation

According to a study by Winther et al., higher concentrations of plasma TMAO were related to mortality, CVDs, and poor renal outcome in patients with type 1 diabetes (137)

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