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It directly stimulates pro-opiomelanocortin/cocaine-and-amphetamine-regulated transcript (POMC/CART) neurons and indirectly inhibits neuropeptide-Y/agouti-related protein (NPY/AgRP) neurons through GABA neurotransmission, reducing appetite and promoting weight loss [40]
Starting with a lower dose helps minimize side effects, and adjustments are made as needed for optimal results
Hydration is also paramount, so keep that water bottle close
Losing muscle slows your metabolism permanently, makes you more likely to regain weight after stopping medication, and robs you of the strength and energy gains that make weight loss genuinely life-changing
Manufacturer savings programs can reduce out-of-pocket costs for eligible patients to $25-$500, but eligibility rules change frequently
These treatments work by regulating appetite, improving insulin sensitivity, and promoting weight loss
