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In ARPE-19 cells the addition of glucose increased intracellular ROS levels and lowers the expression of the antioxidant genes SOD2, CAT, and HMOX1

However, compared to orthopedic injury cases, gut-related reports had more variables like diet changes, alcohol reduction, reduced stress, altered training intensity, sleep improvement, concurrent supplementation, probiotic use, and anti-inflammatory dietary interventions

However, reporting compliance plateaued soon thereafter, with only 4560 percent of all trials reporting results in most years

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