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Tsibadze, N
Circulation 135 (17), 16711673
Type 2 Diabetes# Recommendation : Tirzepatide Reason : Five SURPASS trials with 9,000+ patients, FDA approval, and demonstrated superiority over semaglutide
This gradual titration helps minimize gastrointestinal side effects commonly associated with incretin-based therapies
Yes, there are upfront costs
Altering the pharmacokinetic profile, even while maintaining the same total weekly dose, could theoretically affect receptor desensitization patterns, immune response to the peptide, or metabolic adaptation in ways that have not been characterized
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