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GLP-1 receptors are expressed in the enteric nervous system and in the vagus nerve ( Glp1r mRNA expression, immunofluorescence analyses in Glp1r.tdTomato reporter mice reveal GLP-1R expression in various enteroendocrine cells (Table 1), but not GLP-1+ cells ( Glp1r expression to be within the epithelial fraction instead of crypt, mesenchyme, or smooth muscle layer fractions (Yusta et al., 2015)
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E.Sobrino-PlataJ.Montero-PalmeroM
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats
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The side effect profile is well-documented, serious adverse events are rare, and long-term data is accumulating
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