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The major regulator of autophagy is the mechanistic (also known as mammalian) target of rapamycin (mTOR) signaling, which is closely associated with the activity of mitochondria
Its phenomenal, says Michael Krashes, a diabetes and obesity investigator at the National Institutes of Health
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Recent experimental studies demonstrate that stabilizing mast cells with cromolyn after ischemic stroke reduces peripheral and central inflammation, preserves gut barrier integrity, mitigates dysbiosis, and improves functional outcomes, underscoring the pivotal role of gut-derived mast cells and histamine in post-stroke neuroinflammation (Conesa et al., 2023)
Journal of Cell Biology, 209 (1), 111128
