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In prostate cancer, USP8 inhibition suppresses PI3K/NF-B pathway activation, enhancing anticancer effect of docetaxelsupporting this combination as a more effective strategy for prostate cancer [21]
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Other strengths included the use of objective measures of a range of cardiometabolic risk factors and comorbidities and a robust analytic approach incorporating propensity score methods to reduce potential confounding in the comparison of outcomes between treated and non-treated cohorts
The analysis focused on three drugs classified as GLP-1 receptor antagonists
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