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What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions
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Frontiers in Neuroscience, preliminary reports
These biologically relevant sources of DSBs have diverse end structures, varying from ends that can be directly ligated to more complex end structures that must first be processed by a variety of factors that include polymerases, end-cleaning enzymes, and nucleases (reviewed in ref