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NF-B activation helps ectopic lesions survive, drives the inflammatory cytokine environment in the peritoneal cavity, sensitises nerves to cause pain, and stimulates local estrogen production that feeds further lesion growth (5-9)

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Long-acting, subcutaneously administered, PYY RA are undergoing early phase clinical trials as obesity treatments either alone or in combination with GLP-1 RA (Table 1, NCT02568306 and NCT03574584)

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