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There was a report that Se uptake (as selenite) to the brain increased in lipopolysaccharide treated female mice, whereas in males, no increased BBB permeability for selenite was observed under such conditions (Minami et al., 2002)

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The clinical significance arises when B12 is elevated without a clear exogenous explanation

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Cuman C, Menkhorst EM, Rombauts LJ, et al