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Sleep disturbance: If injecting late in the day, the energy boost may interfere with sleep
It comprised adults with T2D who had discontinued an oral glucose-lowering medication or were treatment-nave
Unlike single-target GLP-1 receptor agonists such as semaglutide, retatrutide is being studied for its capacity to activate three distinct metabolic hormone receptor pathways through a single molecule, a design that places it in a separate category from both mono- and dual-agonist compounds currently in clinical use
Native GLP-1 has a short half-life due to rapid degradation by dipeptidyl peptidase-4 (DPP-4) ( Figure 1 In recent years, growing evidence has highlighted a bidirectional interplay between GLP-1 RAs and the gut microbiome
Endocrine Reviews, 21(5), 579-607
Yang Y, Wang Y, Guo L, Gao W, Tang TL, Yan M
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