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Interestingly, GLP-2 administration leads to a reduction in PTH levels in people with an intact intestine, but not in those with short bowel syndrome, 63 indicating that an intact small intestine is required for GLP-2 mediated suppression of PTH secretion

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As a central transcription factor, NRF2 influences this cell death mode by inducing a variety of genes including SLC7A11, GPX4, FSP1, NQO1, HMOX1, ferritin heavy chain 1 (FTH1), HECT and RLD domain-containing E3 ubiquitin protein ligase 2, and vesicle-associated membrane protein 8 in hepatocellular carcinoma and ovarian cancer cells [85, 86]

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