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GLP-1RA or dual GIP/GLP-1RA added to basal insulin compared to basal insulin titrated with a rigorous intention-to-treat approach is moderately effective in preventing further increase in daily basal insulin dose from achieving treat-to-target glycemic goals ( daily insulin dose, SMD -0.49, 95% CI -0.71

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Kim, Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity in JAMA Health Forum (2025

Wegovy and Ozempic carry the same side effect profile, but the side effects of Wegovy may be more severe because Wegovy contains a higher dose of semaglutide