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Conversely, a study involving individuals with HIV indicated that semaglutide treatment was associated with enhanced performance in visuospatial abilities, language, and delayed recall, implying possible benefits for HIV-Associated Neurocognitive Disorders (HAND) (Atieh et al., 2025)

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Verdict: Limited evidence the absence of human trials reflects a combination of a cancelled unpublished safety study, specific FDA-documented safety concerns, and structural barriers that make large-scale human trials difficult to initiate and fund [4][10][1415]

However, muscle injection can lead to faster absorption and potentially higher peak levels, which may worsen side effects like nausea