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References Falutz J, et al
Given its role in catalyzing the conversion of pyruvate to lactate in glycolytic cancer cells and the observation that LDHA deficiency results in only relatively mild symptoms, such as exertional myopathy, LDHA represents a pivotal and safe therapeutic target (150,167)
Older patients and those experiencing hormonal transitions may need longer treatment courses or ongoing maintenance therapy because their underlying metabolic environment is less forgiving of medication withdrawal
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