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Particularly, tumor growth under hypoxia or mitochondrial dysfunction relies almost exclusively on this reductive glutamine metabolism for lipid biosynthesis (Metallo et al., 2011)
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Larger studies are required to substantiate its role in acute and chronic bacterial and viral infections
( A H ) LC-MS analysis of incorporation of [ 13 C]glucose-derived carbons into glutamate ( A ), -KG ( C ), GSH ( E ), and GSSG ( G ), as well as relative abundance of overall glutamate ( B ), -KG ( D ), GSH ( F ), and GSSG ( H ) among all detected metabolites involving TCA cycle and GSH synthesis after stable isotope labeling with [U- 13 C]glucose on day 7
This is particularly relevant for compounds like Mazdutide Peptide
The relative abundance of identified metabolites was determined by ChemStation (Agilent) by using the GC base-peak value of a selected reference ion
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