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(PubMed) Hedin U, Roy J, Tran PK

Doses ranged from 140 mg to 420 mg, given every 4 or 8 weeks

These neurons undergo reciprocal innervation of each other, so the AGRP/NPY neurons are turned off when the POMC/CART neurons are activated, and vice versa

Biochemistry (Mosc) 89: 18631867

Pro-inflammatory cytokines increase neuronal vulnerability to apoptosis and oxidative stress by activating enzymes such as JNK, ERK, dsRNA-dependent protein kinase (PKR), and IB kinase (IKK) that reduce insulin sensitivity by serine phosphorylation of IRS1 [144, 145]

This is especially true if they have trouble getting in the recommended daily servings of fruits and vegetables