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The meteoric rise of glucagon-like peptide-1 (GLP-1) receptor agonists has transitioned these treatments from niche diabetes management tools to global blockbuster therapies for obesity and metabolic health
A case to highlight here is a Malay baby girl who was born at term and developed jaundice at day 3 of life
As discussed above, endogenous GLP-1 is rapidly degraded by DPP-4, whereby it loses its insulinotropic activity, and preventing this degradation results in increased intact GLP-1 levels, improved pancreatic islet responses (enhanced insulin and suppressed glucagon levels) and beneficial effects on glucose homeostasis
In humans, the rate of taurine synthesis from methionine and cysteine is exceedingly low in comparison with rats (Sturman 1993), because the activity of hepatic cysteinesulfinate decarboxylase (a key enzyme in taurine synthesis) is about three orders of magnitude lower in the young and adult men than that in rats (Sturman and Hayes 1980)
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