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First-generation GLP-1 drugs, like Ozempic, mimic GLP-1, an incretin hormone in the gut that regulates blood sugar, slows digestion, and signals fullness to the brain

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In late 2025, the FDA approved an oral semaglutide formulation (Wegovy oral) for weight management at 25mg and 50mg doses, with clinical trials showing 13-14% body weight reduction

When you eat, GLP-1 is released to stimulate insulin secretion, slow gastric emptying, and reduce hunger

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