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Pure GIP agonists, when tested without GLP-1 agonism, havent shown impressive weight loss results in early studies

TD is known to disrupt the blood brain barrier, featuring loss of occludin, ZO-1 and ZO-2 (179, 180)

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However, in the posterior cortex, CAT activity was reduced in the VPA+LipRSV group compared to the VPA group, indicating that LipRSV treatment may have negatively modulated the enzymes expression or activity, either by attenuating oxidative stress and thus reducing enzymatic defense needs, or through a possible pro-oxidant effect dependent on the region and experimental conditions

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