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However, it was found that obese people are hyperleptinaemic, develop central leptin resistance and are unresponsive to leptin therapy [72]

Changes to the physical condition of the pen, vial, or device such as a damaged seal, cracked cartridge, leaking device, or damaged packaging should also prompt immediate discontinuation of use

GLP-1RAs are synthetic molecules that mimic the effects of the naturally-occurring GLP-1 hormone, including increasing insulin secretion and slowing gastric emptying

Consult your healthcare provider to determine the appropriate duration for your individual needs

In most cases, this is temporary and improves as the body adjusts