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Abstract Importance: GLP-1 receptor agonists (GLP-1 RAs) are widely recognized for their antidiabetic properties, primarily due to their insulin secretagogue action

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Nonetheless, the pharmacological activation of the GLP-1R is clinically beneficial (179), offering an improved glycaemic control with lower cardiovascular morbidity and without the risk of hypoglycaemia associated with some current anti diabetic drugs (173)