Weight loss alone can reduce apnea hypopnea events and nighttime oxygen drops. Tirzepatide (Zepbound) is now FDAapproved specifically to treat OSA in adults with obesity, backed by SURMOUNTOSA trials showing large drops in apneahypopnea index, hypoxic burden, and body weight versus placebo. Semaglutide is not OSAapproved but still improves apnea severity in some patients as weight and visceral fat come down, with emerging data suggesting symptom relief and better functional scores. For sleep apnea driven by obesity, both agents can help, but tirzepatide is the one positioned as a direct OSA drug today
The drug stimulates the release of neurotransmitters in the brain: specifically norepinephrine, dopamine, and serotonin
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Nausea : Both substances could increase feelings of nausea
The hormone also can latch on to receptors on the vagus nervea long cranial nerve that shuttles messages between the brain and organs throughout the body