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Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
L.ZhangJ
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The combination synergistically inhibited cell proliferation and induced apoptosis more effectively than the individual agents, with mechanistic analysis revealing the inactivation of the EGFR/AKT/mTOR pathway, an increase in p53 levels, and enhanced mitochondrial dysfunction, offering a promising treatment strategy for p53 wild-type NSCLC patients
When B12 levels fall, the bone marrow produces abnormally large, immature red blood cells called megaloblasts, which cannot effectively transport oxygen
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