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Compared to the native hormones, retatrutide shows 2.9-fold less potency at the glucagon receptor (GCCR), 2.5-fold less potency at the GLP-1 receptor, and 8.9-fold greater potency at human GIP receptor [1]

Retatrutide-assisted recomposition offers advantages for recreational lifters who want to stay lean year-round, individuals who respond poorly to cutting phases (excessive muscle loss or metabolic adaptation), those who struggle with appetite control and binge eating tendencies, and older lifters where aggressive weight fluctuations may be less advisable

The study indicates this may not be because the patients aren't producing enough glutathione, it may be because glutathione is being used at a higher rate in patients with type II diabetes

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