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The exclusion criteria were: females who were pregnant or experiencing a menstrual period, type 2 diabetes treated using an insulin regimen, malignancy, hematopathy, active tuberculosis, peptic ulcer with gastric bleeding, binge-eating disorder, psychiatric disease, congestive heart failure, clinically relevant renal or hepatic insufficiency, unstable coronary artery disease, cancer or a history of cancer

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Whilst B12 injections are well-established NHS treatments for documented deficiency, lipotropic combinations lack robust clinical evidence and are not routinely prescribed within the NHS

2) with and without further stress stimuli, an effect attenuated by PKC inhibitors [154, 155]

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