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Some studies have suggested that rapid improvements in glycemic control with semaglutide may be associated with temporary worsening of diabetic retinopathy in certain patients, particularly those with pre-existing retinopathy

Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction

PubMed ID: 11713213 Ng FM et al

Heather Smith-Fernandez: Improving the condition of our mitochondria and improving efficient output of cellular energy has widespread effects, and in some cases, these effects are palpable (we actually feel more energy, more focus, less pain, more endurance)