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Some studies suggest that very high caffeine intake might slightly interfere with the absorption of certain nutrients
Although GSH may act as a backup for TrxR to keep Trx in its reduced form 36 , it will be depleted by APR-246, leading to the dramatically increased ROS production due to the simultaneous inactivation of both major redox systems
Biobehav Rev
Another study confirmed the effect on rabbits (9)
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