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Unlike GLP-1 receptor agonists, which primarily enhance insulin secretion and satiety, amylin analogues more directly suppress hunger and promote fullness through central nervous system pathways

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Induction of apoptosis was detected by Propidium Iodide (PI, 1 g/mL) (Sigma Aldrich) and Annexin-V-APC (Immunotools) staining, followed by flow cytometry analysis, using a BD FACSCantoII flow cytometer

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