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It is to understand where the field is going
Kessler describes it as being "at the edge of nausea." He compares it to the way your stomach might feel when you've eaten a bit too much at Thanksgiving dinner
We conducted a detailed subgroup analysis comparing different GLP-1 RA groups to non-GLP-1 RA users
Other research highlights: 30% of GLP-1 users tested positive for SIBO or IMO even after accounting for diabetes (5) GLP-1 medicines caused microbiome changes and altered metabolism in mice (6) GLP-1 medicines tested in humans only had noticeable microbiome changes by 48 weeks (7) Despite not necessarily having slower gut motility, one study found that 88.9% of obese patients had SIBO (8) A meta analysis of people with IBS symptoms, found that up to 78% of people had SIBO, many of whom were undiagnosed (9) Overall, Sun and colleagues (1) could not prove a mechanistic link between GLP-1 medications and SIBO, however they did find that SIBO was twice as likely in GLP-1 users
(85 g) provides 265% of the DV (22,25)
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