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It is possible that the increased binding with mutant FUS/TLS interferes with the normal dynamics of SMN complex assembly and/or trafficking/cycling, therefore leading to dysregulation of SMN function
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No systemic toxicity has been reported in human or animal studies
For fatty liver: 1800 mg, once daily, intravenous drip, for 30 days
involved the creation of ZIF-8 NPs, which were ferrous iondoped and engineered to resemble the membrane of cancer cells
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