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Hold if you have not been stable at the current dose for at least three weeks

In primary lung fibroblasts, MSH reduced SMA expression and cell proliferation (176), while on Tenon's capsule fibroblasts, involved in conjunctival fibrosis, MSH reduced collagen deposition, proliferation and cytokine release (177)

This provides reassurance for combined therapy approaches, though individual risk assessment remains important

Please see Table 1 which summarizes the key findings

Additional metabolic effects include stimulation of fatty acid oxidation, inhibition of gluconeogenesis, and increased energy expenditure