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We defined the ideal number of parasites needed to achieve a rate of infection that was reliably detectable by our high-content imaging platform, with room for the infection rate to significantly decrease or increase and still be detectable, while also not causing too much host cell death

(2023) 7(Supplement_1):bvad114.1292

As erythrocytes lack intracellular organelles, their metabolism is restricted to well-known cytosolic biochemistry: glycolysis, the pentose phosphate pathway (PPP), redox metabolism, oxygen metabolism, purine/nucleoside metabolism, and membrane transport

It's a balancing act, and I think microdosing is used to achieve that

Any firms producing bulk product must also register with FDA in the so-called electronic Drug Registration & Listing System (eDRLS)