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IGF-1 replacement therapy, within physiological ranges, may restore metabolic balance, improving carbohydrate and lipid metabolism while supporting overall metabolic health and nutrient utilization (7)
As noted by Dai et al
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[33] [34] In 2026, the UK Medicines and Healthcare products Regulatory Agency (MHRA) updated its guidance on GLP-1 medication after an increase in reports to the agency's Yellow Card Scheme of acute pancreatitis, with fatalities, in patients taking semaglutide or tirzepatide, to warn of a small risk of developing severe acute pancreatitis
Injection site redness or local irritation has also been reported in patients
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