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Given that mitochondrial bioenergetic alterations appear early in the disease course, they are considered potential primary events underlying synaptic failure, neuroinflammation, oxidative stress, and neuronal loss (Joshi et al., 2018)
Product quality is a major confounder: research-grade material sold "for research use only" is not manufactured to pharmaceutical standards, and contaminants, incorrect concentrations, or endotoxins can cause harms that have nothing to do with the peptide itself
All samples originally classified as GT 2 (7 out of 114) and GT 3 (8 out of 114) were confirmed using Roche-NGS
doi: 10.1038/s41422-020-0379-5 258 SiesH
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Side Effect Management Both compounds have established side effect profiles from clinical trials
