mechanism of action of glp 1 receptor agonists Incretin-based therapies in MASLD/MASH: from GLP-1 to dual and triple agonists Therapeutic Potential of GLP-1 Receptor

However, on the basis of existing medical knowledge, we can speculate the following possible mechanisms: first, as an important antioxidant in the human body, glutathione can scavenge excess free radicals in the body and participate in maintaining the activity of the antioxidant enzyme system (such as glutathione peroxidase and glutathione S-transferase), thereby alleviating the damage to the central nervous system caused by oxidative stress

SARS-CoV-2 can activate mitochondrial ROS production, especially in older individuals having ROS overproduction, enhancing oxidative stress and promoting endothelial dysfunction, cardiovascular disease and lung injury

Seizure 1997

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1980 Dec 25;288(5792):715-7

Given the rapid and increasing uptake of GLP1Ra-based therapies, coupled with the knowledge gap surrounding their impact on clinically relevant bone outcomes in older adults, we conducted an exploratory post hoc analysis of a pilot trial to explore the impact of 20 weeks of semaglutide use on bone density and turnover in older adults with overweight or obesity